Hannah Clapham

Dengue Epidemiology

My research aims to improve our understanding dengue epidemiology and transmission dynamics in Asia with a particular focus on serological data and asymptomatic infections.

Selected publications:

Lam, HM., Phuong, HT., Vy, NHT., Thanh, NTL., Dung, PN., Muon, TTN., Chau, NVV., Rodríguez-Barraquer, I., Cummings, DAT., Wills, BA., Boni, MF., Rabaa, MA., Clapham, HE., Serological Inference of Past Primary and Secondary Dengue Infection: Implications for Vaccination, (Journal of the Royal Society Interface, 2019 July, 10.198)

ten Bosch, Q.A., Clapham, H.E., Lambrechts, L., Duoung, V. ,Buchy, P, Althouse, B.M., Lloyd, A.L., Waller, L.A. , Morrison, A.C., Kitron, U., Vazquez-Prokopec, G.M., Scott, T.W. & Perkins, T.A.,  Contributions from the silent majority dominate dengue virus transmission (PLoS Pathogens, May 2018, https://doi.org/10.1371/journal.ppat.1006965)

Clapham, H.E., Cummings, D.A.T and Johansson M.A., Immune status alters the probability of apparent illness due to dengue virus infection: evidence from a pooled analysis across multiple cohort and cluster studies, (PLoS NTDs, 2017 September, https://doi.org/10.1371/journal.pntd.0005926)

Nisalak, A.*, Clapham, H.E.*, Kalayanarooj, S, Klungthong, C., Butsaya Thaisomboonsuk, B., Fernandez, S., Reiser, J., Srikiatkhachorn, A., Macareo, L.R., Lessler, J.T., Cummings, D.A.T & Yoon. I.  Forty years of dengue surveillance at a tertiary pediatric hospital in Bangkok, Thailand, 1973 to 2012 (Am J Trop Med Hyg. 2016 Jun 1; 94(6):1342-7. doi: 10.4269/ajtmh.15-0337.)

COVID-19

Modelling Immunity and Infectivity

I am interested in modelling the within-host virus and immune dynamics of infectious diseases. Past work in this area modelled dengue virus and antibody responses during infection, modelling the antibody response after infections, and understanding how individual immune dynamics impact transmission dynamics. Future work in this area will merge antibody and viral data at the individual and population level and expand this work to other arboviruses.

Selected publications:

Clapham, H.E., Rodriguez- Barraquer, I , Azman, A.S., Althouse, B.M., Salje, H., Kalayanarooj, S., Gibbons, R.V., Jarman, R.G., Nisalak, A., Thaisomboonsuk, B., Nimmannitya, S., Yoon, I., Alan Rothman, A. & Cummings, D.A.T. Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection (J Infect Dis. 2016 May 1;213(9):1428-35. doi: 10.1093/infdis/jiv759.)

Clapham, H.E, Than Ha Quyen, Duong Thi Hue Kien, Simmons, C.P. & Ferguson, N.M. Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance (PLoS Comput Biol. 2016 May 23;12(5):e1004951. doi: 10.1371/journal.pcbi.1004951.)